Kainic acid definitions
| Word backwards | ciniak dica |
|---|---|
| Part of speech | noun |
| Syllabic division | kai-nic ac-id |
| Plural | The plural form of the word "kainic acid" is "kainic acids." |
| Total letters | 10 |
| Vogais (2) | a,i |
| Consonants (4) | k,n,c,d |
Kainic acid is a potent neuroexcitatory amino acid that is derived from the red algae digenea simplex. It is known for its ability to induce seizures and neurotoxicity in the brain, making it a valuable tool in studying epilepsy and neurodegenerative diseases.
History of Kainic Acid
Kainic acid was first isolated in 1953 from the red alga digenea simplex by H. Morisawa and J. S. Clark. Its name is derived from the Japanese word "kaina" meaning "seaweed". Since its discovery, kainic acid has been widely used in neuroscience research due to its ability to selectively activate specific subtypes of glutamate receptors in the brain.
Mechanism of Action
Kainic acid acts as an agonist at the kainate receptor, a subtype of glutamate receptor in the brain. By binding to these receptors, kainic acid causes an influx of calcium ions into neurons, leading to cell excitation and eventual cell death. This mechanism of action is responsible for the neurotoxic effects of kainic acid.
Research Applications
Due to its ability to induce seizures and neurotoxicity, kainic acid is commonly used in animal models to study epilepsy, neurodegenerative diseases, and excitotoxicity. Researchers use kainic acid injections to mimic the effects of seizures and study the underlying mechanisms of neuronal damage.
Overall, kainic acid is a powerful tool in neuroscience research, providing valuable insights into the mechanisms of neurodegeneration and epilepsy. Its ability to selectively activate glutamate receptors makes it a valuable compound for studying brain disorders and developing potential therapies.
Kainic acid Examples
- Researchers are studying the neurotoxic effects of kainic acid on the brain.
- Kainic acid is commonly used in neuroscience research to induce seizures in animal models.
- The mechanism of action of kainic acid involves overstimulation of glutamate receptors.
- In some cases, kainic acid can cause excitotoxicity leading to neuronal death.
- Studies have shown that kainic acid can affect synaptic transmission in the hippocampus.
- Pharmacological studies have explored the potential therapeutic properties of kainic acid derivatives.
- Kainic acid toxicity can result in cognitive impairments and memory deficits.
- The bioavailability of kainic acid varies depending on the route of administration.
- Kainic acid-induced seizures are a well-established model for epilepsy research.
- Some marine algae produce kainic acid as a defense mechanism against predators.