Amrinone definitions
| Word backwards | enonirma |
|---|---|
| Part of speech | Amrinone is a noun. |
| Syllabic division | am-ri-none |
| Plural | The plural of the word "amrinone" is "amrinones." |
| Total letters | 8 |
| Vogais (4) | a,i,o,e |
| Consonants (3) | m,r,n |
Amrinone is a phosphodiesterase inhibitor used in the treatment of heart failure. It works by increasing the levels of cyclic adenosine monophosphate (cAMP) in the cardiac muscle, leading to positive inotropic effects. This results in increased contractility of the heart muscle, allowing for improved cardiac output.
Mechanism of Action
Amrinone inhibits the breakdown of cAMP by inhibiting the enzyme phosphodiesterase. By doing so, it increases the levels of cAMP within the myocardial cells, leading to enhanced calcium uptake and improved muscle contraction. This mechanism of action makes amrinone a valuable agent in the treatment of heart failure.
Indications
Amrinone is typically used in patients with severe heart failure who do not respond adequately to other medications. It is often prescribed in cases where traditional treatments have proven ineffective, or as a bridge to heart transplantation. However, due to its potential side effects, amrinone is reserved for patients who cannot tolerate other heart failure medications.
Side Effects
Common side effects of amrinone include hypotension, arrhythmias, thrombocytopenia, and elevated liver enzymes. Due to these potential risks, close monitoring is required when using amrinone in clinical practice. Physicians must balance the benefits of improved cardiac function with the potential for adverse reactions when prescribing this medication.
Conclusion
In conclusion, amrinone is a phosphodiesterase inhibitor used in the treatment of heart failure. By increasing cAMP levels in myocardial cells, it enhances cardiac contractility and improves overall cardiac function. While effective, amrinone comes with potential side effects that require careful monitoring and management. It remains an important option for patients with severe heart failure who do not respond well to other interventions.
Amrinone Examples
- Doctors may prescribe amrinone to patients with heart failure.
- The nurse administered the amrinone infusion to the patient in the ICU.
- Researchers are studying the effectiveness of amrinone in treating pulmonary hypertension.
- Pharmacists must be knowledgeable about the side effects of amrinone.
- Patients taking amrinone should be monitored closely for any adverse reactions.
- Amrinone is sometimes used during cardiac surgeries to help improve heart function.
- The cardiologist recommended a low dose of amrinone for the patient's condition.
- Amrinone can interact with certain medications, so it's important to inform your healthcare provider of all drugs you are taking.
- After receiving amrinone therapy, the patient's cardiac output improved significantly.
- Amrinone is classified as a phosphodiesterase inhibitor medication.