Malonate meaning

Malonate is a substance that inhibits the enzyme malate dehydrogenase, affecting the citric acid cycle.


Malonate definitions

Word backwards etanolam
Part of speech Noun
Syllabic division ma-lo-nate
Plural The plural of malonate is malonates.
Total letters 8
Vogais (3) a,o,e
Consonants (4) m,l,n,t

What is Malonate?

Malonate, also known as dimethyl malonate, is a simple dialkyl ester of malonic acid. It is a colorless liquid that is commonly used in organic synthesis as a building block for the production of various compounds.

Uses of Malonate

One of the primary uses of malonate is as a precursor in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It serves as a starting material for the synthesis of barbiturates, vitamin B1, and other important organic molecules. Additionally, malonate is used as a reagent in organic reactions to introduce the malonate functional group into molecules.

Malonate in Biochemistry

Malonate is also known for its role in biochemical studies. It is a competitive inhibitor of the enzyme succinate dehydrogenase, which is involved in the citric acid cycle. This property of malonate has been utilized in research to study the mechanisms of enzyme inhibition and metabolic pathways.

Health and Safety Considerations

While malonate itself is not considered highly toxic, like many organic compounds, it should be handled with care to avoid skin contact or inhalation. Proper ventilation and personal protective equipment should be used when working with malonate to ensure safety in the laboratory or industrial setting.

Organic synthesis and biochemical studies often rely on the use of malonate as a versatile reagent. Its role in various chemical reactions and as an inhibitor in biochemical processes makes it a valuable compound for researchers and scientists alike.

Overall, malonate plays a crucial role in the field of organic chemistry and biochemistry, showcasing its significance as a building block for a wide range of applications.


Malonate Examples

  1. Malonate is commonly used as a precursor in the synthesis of pharmaceuticals.
  2. The malonate ion plays a key role in the malonic ester synthesis reaction.
  3. Organic chemists often use malonate derivatives in various reactions.
  4. Malonate compounds are important intermediates in organic chemistry.
  5. Malonate esters can undergo decarboxylation reactions under certain conditions.
  6. The malonate pathway is utilized by some microbes to produce energy.
  7. Researchers are studying the reactivity of malonate in different environments.
  8. The malonate anion has a unique structure due to its two carboxyl groups.
  9. Malonate derivatives can exhibit fluorescence properties in certain solvents.
  10. Malonate is often used as a building block in the synthesis of complex molecules.


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  • Updated 02/04/2024 - 16:41:37